To my eye, almost every single photograph is vacuous.
The exceptions are: a) personal photos, which have meaning for me, but are probably vacuous for you. b) the incredibly rare single photo with enough of something I cannot put my finger on to stand alone. Even those mighty single photos exist, more often than not, in the context of someone's oeuvre, and so I cannot be sure that even many of these truly stand alone.
Only with groupings and in context can I hope to make sense of a photograph, in almost all cases.
Conversely, almost any photograph can be made powerful and meaningful when placed into the situation, when placed next to the right other pictures, the right words, the.. I don't know what else.