Maurice and all, I thought the problem might have popped up with the latest version (1.12.0) of Studio, so I checked it on another PC that has an older version (11.5.0) installed. I see the exact same problem there, so it's not a recent version issue; nor is it restricted to just one of my computers.
I also checked to see what happens when other, non-Studio, Topaz plugins are called up directly from Photoshop rather than going through Studio. No problems there, the 100% view looks the same as it does in PS.
The HD Preview button, when invoked in Studio, induces a marked change when the image is set to FIT the screen--it becomes much sharper. After clicking the IN button one or a few times, the effect is still there but reduced. By the time I get to 100% enlargement, the HD Preview effect is completely gone.
Since Plugsnpixels' results on a Mac look good, and those of us reporting this problem are all using PC's and Windows, maybe it is the version that runs on PC's that is at the root of it. I'm wishing now that this problem was in it's own thread, so that others might more easily notice it and weigh in with more data points.
Maurice, please do let us know what happens with your support ticket. This is a pretty serious issue.