On my 2nd hand 9900, I had one or two nozzles in one color that were clogged for several years, then one day, they were clear and that was a couple of years ago. Nothing showed on the prints and I ran hundreds of feet of both canvas and photo stocks. My printer is pushing 10 years old and is still going strong with the head firing all the nozzles.
Usually, I try to run a check before anything critical and if there's more than a 3-4 gaps, clean just the pairs or if it's in more than 3 channels, run a full cleaning cycle and start printing.