I had a somewhat similar but a little different experience with my P400 recently. I haven't been doing any major printing on it lately so I just do a nozzle check every once in a while. Everything looked normal last week except that I noticed that nozzle patterns for successive colors didn't look aligned so I decided to do an alignment routine. When I subsequently did the nozzle check again to see that made any difference, I noticed the Red one had quite a few missing nozzles. So I thought what the hell, how did it go bad by just doing the alignment. On to the head cleaning and the thing got even worse. Did an another one (watching the ink levels go down) and the thing got worse still. Ran out of the Red ink at the end so the printer refused to print any more. Replaced the Red cartridge. Nozzle check: now the Red is fine but Yellow and Magenta is kaput. The Yellow is flashing low, Magenta is not but it is on the low end. Found this reference saying that the when the cartridge is low, it may show clogged head.
https://www.marruttusa.com/printer/support/epson-sc-p400-help.php#bloSo I replaced the Yellow with a new one. Nozzle check: Yellow is good now. Magenta is still missing a few. I am out of Magenta so I would not know until I get one and replace. But from the looks of things for my P400, it does seem bad nozzle check is due to low ink. But so far it is limited to the particular ink that is low and not the Black one as experienced by others on this thread.
So now the small 14ml cartridges are now even smaller since I have to toss out the last few ccs because of problems with the resulting nozzle firing....Damn you Epson!
:Niranjan.