When I shoot tethered I like to have the Loupe tool selected to check focus as I go. In version <10, I could click in the browser on thumbnails to switch pictures - while having the Loupe tool selected (and click-hold on a thumbnail would make the Loupe tool work as usual).
In version 10 this no longer works - the Loupe tool doesn't switch between pictures when I click on thumbnails. This is a very very very very very annoying change and I hope it will be reverted.
Win7 64bit, build 10.0.0.225
Edit: the old way works while a catalog is loading but not after it's done loading