Just passing along that great as the new CMOS backs are at 400/800/1600 asa, for me, that 'MF look' gets lost as the ISO increases.
I needed to shoot at 400 the other day, and something was bothering me when I looked at the files. I think it was simply this: the buttery smoothness of a large resolution back is lost, and you are starting to look at the 'grain' structure, rather than the thing itself: skin, metal, glass, sky - do not have 'grain' after all. A key part of the MF look for me is that complete smoothness you have on a large print that has not been upsized, or pushed in any way, allowing the true surface/textures to come through. You see it at asa 35/50 on the CCD backs, and 100/200 on the CMOS ones. Above that it starts to look closer to a small sensor pushed. Strange how these subtle things play out.
Very happy still to have this high ASA option to hand - there are things you simply must have 400/800/1600 for, and it's great it's truly usable, unlike CCD backs which fall apart really fast, but... it's still not without a cost.