I have the the Otus 55mm, 85mm, and the 135mm f/2 (which I consider of similar quality), and the 28mm f/1.4 Otus on order.
I happen to shoot on a tripod, which I don’t consider a shortcoming of any kind. For the stacked, close-up work that I do, it is necessary.
I use the Nikon D810 in LiveView, along with an early Zacuto Z-Finder, and find no problem focusing, although anything earlier from Nikon (D800E, etc.), does not quite make it for me in that regard.
I ended up with the Otus lenses only because they are more highly corrected than other lenses that I have, and I have about eighty very high-quality lenses, although since acquiring the Otus series, I am selling off more and more of them, because I never use them anymore.
In my work, sharpness IMO depends on color correction, and many of my older lenses, like the Zeiss 100mm Makro-Planar are just not corrected well enough, although that lens is sharp. And I am fighting an uphill battle with the Otus series, because they really are not made for close-up work. I use the thinnest of extension on some of these lenses, the Nikon K1 Ring (5.8mm), which allows me to work a bit closer without too much degradation of the lenses.
My point here is that I am sure I am part of a subset of a subset of a subset of photographers and don’t really count, number-wise. I mean: who wants to shoot on a tripod and stack focus, with extension and also viewfinder enhancement, using highly corrected lenses aside from a few?
I did not get where I am by being trendy or going for high prices. I resisted the Otus series of lenses for quite a while for the obvious reasons that they don’t fit my very specialized close-up work… and they are way expensive. Then, based on reviews of people I respect, I broke down and tried the Zeiss 135-f/2 and was shocked at what that lens could do, compared to the other Zeiss lenses I own, like the 50mm, 100mm Makro-Planars, which I, as mentioned, never use.
Perhaps I am an exception because I shoot them (mostly) wide open, where the depth-of-field is razor thin, but I stack focus, which practically amounts to painting (layering) focus to make what I wish stand out, and allow the rest to got to bokeh. Yet, I also find that single-shots at f/16 with the Otus series stand up very well.
For a while I had a shoot-off going on my mind between stacking wide-open and single photos at around f/16, but for me, the stacking won out.
So… as I browse through this thread, I can understand most of the opinions here and why they might be held. I just wanted to add my own: that for very specialized work, these lenses are the best I have ever used and worth every penny.
P.S. I tend to have a whole series of lenses that I love, each of which has its own special style and reason for use, like the Voigtlander 125mm f/2.5 APO-Lanthar, the Leica 100mm Elmarit-R APO, and many industrial lenses like the El Nikkor 105mm APO, the CRT-Nikkor, the Printing Nikkors, and others. I feel the same way about ultra-Wide-angle lenses like the Venus 15mm macro, etc.