Hi,
I don't own a 5Ds but I may still have some input on the issue.
The first point is that it depends on what lenses you use. Stellar lenses on the Canon may match decent lenses MFD. But there are stellar lenses for MFD, too.
The second point is which MFD? A small format 1.3X crop 50 MP MFD may have little advantage over the 50 MP 5Ds, but an 80 MP back on a technical camera with a good APO lens, that is a different story.
The third point is what are you evaluating? Regarding sharpness, I think the Canon will do quite OK if paired with an excellent lens. But clean deep shadows are not the forte of the Canon sensors.
My personal experience is with Sony A7rII and a Hasselblad 555/P45+ combo. That system is old, but a couple of the lenses are quite good. I would say that the Hasselblad/P45+ may have a small advantage when pixel peeping, but it would be hard to tell them apart in print.
A final point is that you can buy a 5Ds with an excellent lens for 8k$ (or even less) that doesn't get you a low end MFD back and it may be what you would pay for a high end Rodenstock HR wide angle. That said 8k$ buys you a Pentax 645z with one or even two decent quality lenses.
I have seen some comparisons of high end DSLRs with low end MFD, and I have the impression that the MFD systems had a small edge in the resolution area. But making objective comparisons may be very hard. It may be necessary to stop down an MFD system a bit more for equivalent depth of field. A high end DSLR may perform best at f/5.6, but a comparison my be at f/11.
Best regards
Erik
Have any medium format owners run some test? Curious to hear, thanks!