Spot removal should be done before you start making the image look nice. Just like any cloning or healing. Click once for the TC adjustment, click again to reset it. If that's a hassle, then I suppose one should use a different technique. I find going back and forth between a high contrast black and white image and the actual color image I am working with an unnecessary distraction.
If the shots you are correcting are all taken in sequence or reasonably close in time, you can correct a blank frame (a shot of the sky at some small aperture, for example - aka a "Dust Map") and then sync the Spot Removal, saving time on correcting all of the images you edit. Because you can sync **just** the Spot Removal edits across images, you won't overwrite all of the adjustments you may have made to your images already, like a custom tone curve.
Whatever works for you.
kirk