After further research;
Yes the hot key can work, but here there are two installed plugins with the same keyboard short cut which causes the hotkey utility to fail.
Next question is it possible to change the default keyboard short cut for a plugin ?
(yes, I know it's possible for the program itself)
<later>
Yes, it was possible to change the shortcut for the clashing plugin (AnyFilter) so now fully resolved by killing one of the plugin's shortcut.