Above 3200 ISO the noise does get nasty so I can see Eric's point. But in this article no one is suggesting that anyone shoot final images at anything above native ISO. The whole point about shooting throw away test frames at 6400 is to determine the optimal exposure before committing to a long final exposure. It's convenient that the exposure time in seconds at ISO 6400 is the same as the exposure time in minutes at 100 ISO. Shooting at native ISO produces far cleaner images than anything higher.
Actually, if you are doing long exposures you are much better off using a higher ISO gain, and stacking multiple shorter exposures. Read noise in photoelectrons drops nearly a stop for each doubling of ISO from ISO 100-400 on Canons, and substantially from 400 to 800. Stacking N images results in read noise that is sqrt[N] times the read noise of an individual image (and substantially improves nonfixed pattern noise). So for instance four one minute shots at ISO 400 stacked will have about half the read noise of one shot of four minutes at ISO 100. The shadows will be much cleaner in the stacked image. Photon capture will be the same, but camera electronic noises will be lessened.
On the other hand, at ISO 1600 and beyond read noise on Canons levels off, and so the sqrt[N] penalty for stacking N images is not compensated by any gain in reduced read noise per image at higher ISO. There is a sweet spot, and I believe most good astrophotographers are shooting at around ISO 400 or 800. Intermediate ISO's are a waste of time on Canons (zero benefit in terms of read noise).
If the article is correct, it seems that the buffering for LENR is rather idiotic. The whole point is to take a dark frame image to subtract thermal noise. If you've got four images in the buffer, why take a separate dark frame for each rather than a single dark frame and subtract it from all of them? It would drop the downtime substantially!