Andrew, since it still is raw data in LR, nothing do is ‘irrevocable’. However, many Adobe profiles, particularly ’Adobe Color’ , are, at times, a bit heavy handed with added tone curve (even with highlight rolloff) and other adjustments. Once applied, these are difficult, to impossible, to pull back. This often happens when camera exposure pushes highlights right to edge of being blown, then the highlights get pushed over edge by the profile. In these cases, and often others, I find a linear profile a better starting point. But I am sure you know all this.
Would this [linked video] count as proof of concept?
It certainly qualifies as proof of the excessive use of adjectives, superlatives, exaggerations, and !!!exclamations!!!