In my hands, yes there was a difference: 16 bit would crash the driver or cause the paper to spit out huge sheets of un-printed paper, where 8 bit spools would not. This problem arose with physically large files, large print dimensions at large dpi, and 16 bit. Once I found 16 bit selection in the driver to be the cause, I have never again printed in 16 bit with no regrets.
John-