My experience! -YMMV
Anything more than 1 or a few very small gaps showing on a nozzle pattern, or what appears to be a crooked line (deflection), can usually be considered a clog. Anything else, including but not limited to a few lines or a complete channel missing, is usually air in the nozzles! These machines do not differentiate a clog from no ink in the nozzle, (a dropout).The machine simply reports as a "clog". A "cleaning" cycle does one of two things, recharges the nozzles with ink due to air in the nozzle(s), and or "cleans the outer surface of the head at the nozzles with the wiper. You have to learn which is which, and treat the issue correctly, without freaking out and overdoing cleanings, especially power cleans.
A couple of Likely Causes...
A Black ink switch with 1 or more very low carts which allows back suction during the switch, resulting in drop outs.
There is a very good reason why the machines are programmed to do a cleaning cycle after a Black switch, and that is to recharge the nozzles in case there was air drawn in. People trying to save ink, overriding this process by running in maintenance mode are wrong in doing so and taking risks! Always make sure your carts ,especially either black cart or the LK which is on the same channel is not extremely low before doing a switch. If you do get a dropout do 1 or 2 regular pair cleans and it will usually come back.If not print a B&W or color gradient on some office paper to exercise the black nozzles or which ever color channels have dropped out then do another check... repeat if necessary.
Low pressure in the lines due to 1 or more very low carts, or too frequent cart removal to compensate for infrequent printing and the fear of ink settling in the carts , ("I'm shakin it boss")...
Will ruin the cart seals or damage a needle and allow air into the lines at the cart seals, resulting in air bubbles and gaps later as those air bubbles form a block of the ink flow to the nozzles. The dampers are not always successful in removing larger bubbles in the lines resulting in a dropout. Epson warns about this in the manual!