Hate to ask a stupid question, Mike, but have you tried turning the unit off, letting it rest a bit then re-powering it to re-pressurize the carts? How about a PK/MK switch, or putting in a newer/fuller MK cart to see if by chance the cart is the issue?
I'm sure you've heard others say that complete (or near) loss of an entire channel often isn't a clog but rather an air-bubble in the line that must be cleared, or issues with the dampers. I occasionally lose my enitre PK/MK channel when I do an ink swap, and now and again when I have a 'minor clog" (break in 1-2 lines, less than 5-25% of the line at most) and perform a cleaning. As terrifying as it is to me when that happens, I often find that powering off, swapping another cart (I have a nearly full MK and one with about 20% left) followed by a print that drives a lot of ink thru that channel the next day brings me nearly completely back, and often once it's more than 90% back a standard cleaning finishes the job. If 2-3 tries doesn't competely bring back the remainder, I refill my internal humidifier with warm water and let it sit overnight. The next day I'm usually back. Whether the humidifier trick has anything to really do with it nor not...I haven't a clue.
Sorry you're going through this, sincerely hope you're not facing a pressing deadline on any work. Good luck on getting it back.