OS: Yosemite
CarbonCopyCloner
Thanks, Wayne, the suggested fixes DID work, but with a small precaution :
1 - create Spotlight exclusions
2 - run 'reset LaunchServices'
3 - disconnect all backup drives from the Mac, and reboot
4 - with external drives still NOT connected, open all programs affected once ( i.e. Lr, Ps, C1 etc) and then close
5 - shut down and reconnect all external drives
6 - good to go