I don’t print that frequently, so when cartridges run low they stay that way for a while. I haven’t notice any increase in clogging from that.
As far as running the printer till it runs out of ink, I do that all the time. It doesn’t actually run dry, but at some point the printer will refuse to print until a new ink cartridge is installed. After the new one is installed, (even mid print) it continues without issue.