The Pentax wireless TTL flash system worked just fine with the 645D - roughly identical to how the canon or Nikon systems work.
Personally, I dislike speedlights, and in particular dislike $500 speedlights. So I use strobes. I'm not sure if the Profoto TTL system will eventually be made to work with Pentax, but perhaps. The B1's are really nice units. First strobes that compete favourably with the PB Einsteins imho. With the air remote, you can control the profotos remotely as well.
Frankly, I would simply get a bunch of PB strobes with the remote radio system that allows full control over the strobes, via the radio transmitter atop the camera. It will cost not much more than three or four of the top-end Pentax speedlights. But if you need portable power, those may be your answer.
- N.