There really are a multitude of issues/factors, either singular or a combination, that may be involved in a blocked or clogged head/nozzle----which makes it exceedingly difficult or impossible to state that a blockage must be from factor "x" without knowing the particulars/condition of a specific printer. Typical Epson tech approach is to start replacing parts (educated guess) and continue doing so until the problem is resolved. (e.g., head, wiper, dampers, capping station....). If the printer is under warranty, then no problem. But if you have to foot the bill, then sometimes it may be worthwhile to dig around a bit first.
I think it would be worthwhile to try Tom's suggestion (INIT FILL) before throwing in the towel.
ken