Haven't used the Hy6 with a Sinar back, but extensively with a Leaf AFI II-7 (33mp) back. No real issues. The AF works fine for me, esp. with the 50 and 80 (just tried the 180 and its OK, but not as seamless as the other two).
The list of lenses made is impressive, but could be edited by simply noting the PQ and PQS as two available shutters for a given lens. The optics didn't change.
There is an inevitable discussion of the difference between a manual focus lens, the AF, and then the AFD (sometimes improved and different).
One of the hidden benefits of this system is the ability to use manual focus lenses (not so expensive on the used market), top tier quality. easy to use with the Hy6 focus confirmation. Compared to other systems (e.g. Leica S) with expensive lenses, one can build a Hy6 system with several additional lenses. And have lenses one would normally not spring for. I'm not saying they are cheap but at c. $2k for the Hy6 MF lenses, its not out of the realm to add a few. Having started with Rollei 6003 in 1992, the lens stable has gotten a bit fuller over the years.
One could also pick favorites on that list of lenses. I'm not a fan of the zooms, which are behemoths, but I've seen results from the 60-140 AF on an 80 mp back, and it was impressive (assuming weight/size were not an issue!).