I do what you are proposing often with Lightroom, just as Geraldo has said. You could print the same file as many times as you want, in the same size or in different sizes, and work from only one source file.
Funny, only minutes ago I got an email advert from Lasersoft, mentioning their Print Tao 8 RIP software. Since I trust the company I went to the product page and read testimonials about this RIP. None of the testimonial told me what I needed to know to make a purchase, and that is, "What does Print Tao 8 offer that Lightroom doesn't ?". That it would cost me $700 for our Epson 4900 and 9900 machines, enough to buy Lightroom for all of my friends, increases the contrast for me.
I can't help but recommend printing from Lightroom which is useful in so many other ways as well.
John Caldwell
I was doing a couple of "RIP" trials recently: Mirage3 and Print Tao
Here's what Print Tao does that LR doesn't.
It will automatically size a roll according to the prints you want to make. No more creating a custom size, saving it as a preset, and hoping you remember crossing all the "T's" in order for it to work correctly.
You can also custom cut the roll to any length you like. I like this feature. If you nest a bunch of photos, and the print ends up being 60" long, you can tell it to cut em off in 30" sections making the media easier to deal with.
The one thing it doesn't do is gallery wraps. Nor does LR.
Mirage will not custom cut, but it does gallery wraps, so I went with that one.
The real selling point to me was that I could drag several images into either software and it does everything for you. Just hit print.
My wife likes to download PDF's for craft stuff. No more importing them into either Adobe program and doing all the sizing, setting the printer up, etc. Just drag it in, and hit print. Huge time saver.
I would strongly suggest downloading the trials and playing around. Mirage's trial is relatively short but it gives you full functionality.
Print Tao's trial is longer (indefinite?") but watermarks the pictures.
Oh yeah, both are Mac friendly.