Thanks for the article Jeff. It was definitely enlightening, as sharpening is one of those adjustments that slightly confuses me. The reason I would often sharpen last, or near the end of my workflow in LR, is because I know the adjustments aren't rendered until the file is exported. And then they are rendered in the optimal order (Adobe's optimal order at least). It wasn't until I began working a lot with SEP2 that I found my overall work flow wasn't ideal. But I think I'm on the right track now.
With regards to output sharpening, I am still a little confused. I know for printing, resolution size is set and output sharpening is applied. But staying away from the topic of printing, and just looking at an export to JPG, LR gives a couple of sharpening options...one of which is "Sharpen for Screen."
I've noticed that when I apply "Sharpen for Screen" to a TIFF file, after it has passed through SEP2, it comes out noticeably different than it does if output sharpening was not applied. Generally the image is brighter and more course, which may be exactly what that sharpening was supposed to do and it just isn't to my taste. But my original thought was, I'm over sharpening or sharpening grain after the fact. It's trial and error to be sure, but from now on I will certainly optimize the image in LR, including sharpening, before heading to SEP2.
P.S. Ecosse, I do agree the structure sliders in SEP2 provide a good bit of apparent sharpening, at least to my eyes they do.