Hi,
Cropping in LR does not change the size of the file since the crop is merely an instruction and can be changed at will. A crop in PS combined with "Image Size" is what will result in an small or ginourmous file. Whenever possible, which in my case is most of the time, I adjust my images (DNG from Leica and CR2 from Canon) in LR and print from there: 4 by 6 inches or 20 by 30 inches from the same file.
Jean-Michel