The flange focal distance for Nikon F-mount is 46,5 mm, the flange focal distance for Leica S-mount is 53 mm, according to David Farkas. I've tried to find a Wiki on the Leica S mount, but couldn't find it. Still, looking into my camera I think the flange focal distance indeed isn't much longer than 5 cm.
So there'd be 6,5 mm space for an adapter, which would make it physically possible. I don't know if there would be enough room for an integrated microprocessor that would allow the use of all the original functions of Leica S lenses.
It would be great if the autofocus system and manual override functions of the lenses were preserved. The same goes for the integrated central shutters of the CS lenses, though that would be very difficult because the Nikon mount has no protocol for leaf shutters, I think. Full electronic aperture control should allow the use of aperture priority, shutter speed priority, and program AE modes.
I think inevitably adapters will come, question is how smart they will be.