SuperDuper handles cloning local drives well. It's what I do.
Buy drives in triples. Put your working data on one drive. Clone via SuperDuper to another drive after each work day. Once a week, take the current back-up drive at work to your off-site storage (for me, my house), and then bring the back-up drive bring the back-up drive that was off-site to work. I carry just the drives, leaving the electricity adapters and data cables in place.
Never have all three drives in the same physical location.
IME, spanning back-ups across more than one drive requires to much administration (in short, I have to think about what's where). Your data is worth the cost of a new 3 TB drive. (If I understand, you are asking whether you can use SuperDuper to span a back-up of your 3 TB drives to three older drives.)
ChronoSync get recommended regularly. I haven't looked into it because I don't have high-speed Internet at my studio.