It's just me using it for processing photos, printing from photoshop, using my accounting software and using the internet. I only do those things from a limited user account which means I only use an admin account for adding, updating or removing programs. Both those accounts have strong passwords and I have "fast user switching" turned off. Because of those practices, I am comfortable not using any anti-virus software.
It's connected to the wifi internet and both my printers via usb.
My main concern is what my only computer is exposed to by having other peoples thumb drives plugged into it and the autorun.ini or exe files that most usb sticks initialize with and seem to be used to transfer malicious stuff.
I'm assuming that others with the same concerns would likely be relying on some kind of anti virus software as I can't really come up with any other ideas to protect myself. The only thing I really thought of was to use a separate linux laptop to act as a buffer between the computers, but in all likely hood, any malicious files/programs would just pass through linux without affecting it only to eventually be passed on to my windows desktop anyway.