When it comes to maximizing depth of field it does not really differ on sensor size as you can stop down to compensate -- for the same resolution it's a zero-sum game, except that shutter speed gets longer. If your Nikon is a 36 megapixel D800 it will be hurt more by diffraction on pixel peep than your 22 megapixel Aptus, ie you will experience DoF to be a larger challenge on the D800.
With the 22 megapixel 48x36mm back it is virtually no difference between f/11 and f/16 in terms of diffraction, and f/22 is not too bad. If you need f/22 do use it.
For a lens as wide as 35mm there are quite few cases you'll gain from tilt, so don't worry to much about missing that. If you shoot with a low tripod (close to the ground) and very close foreground you'll get DoF challenges though, but for normal standup compositions it should be relatively easy to get all scene reasonably sharp for 35mm.