Hello--More than likely you will be entering the Park from the East side Denver (Estes Park) of the Divide. My suggestion would be to spend the majority of your time on the West side, however, giving the East side some time as well but you would have to go over Trail Ridge Rd--allow a day.
The East side will be teaming with point & shooters--drive over the Pass & spend time on the West side in the smaller communities such as Grand Lake, Granby, Parshall et al---since the Colorado River's headwaters are on the West side--just follow the Colorado River & its offerings,communities Hot Supher Springs, Kremmling, --following the Colo River down to Dotsero( In particular the old Colo River Rd from Kremmling to Dotsero) to Glenwood Springs & beyond all the way to Moab.
Time will be your nemesis.
Raymond---Edwards, Co--In the Vail Valley--a stone's throw away from the Colo River