I have LR4, which I believe is the same as LR5 as far as noise reduction go. IMO, Dfine is both easier to use and a more powerful program. It is easier to use because it's automatic noise reduction setting is good most of the time. No need to worry about adjusting sliders, which can be a daunting task for newbies or those who have trouble deciding how much noise reduction to apply. It is a more powerful program because you can choose where to measure noise as well as use control points to target noise reduction.