I may be one of the only people here that is really happy with Photoshop as-is. I would like it if all the bugs got fixed though.
(the healing bug that looks like an oil slick when healing on a semi-opaque area of a layer, The fact that CS6 doesn't save all the time to servers, and a few others).
The Just Do It initiative was a good one where Adobe fixed, updated or tweaked many of the old tools that needed it. There are still more that need attention.... (transform tool, paths, and MANY more...).
And of course performance issues can always be improved.
I am not a Lightroom user so I rely heavily on Bridge for file browsing. I know many others that do the same.
I really dislike Lightroom because I am using any one of 5 different computers to work on in a given day accessing files on portable drives or from a server. Lightroom and the catalogs don't play nicely on a variety of different machines. I thought Lightroom would be a great application but to be honest, I can work just as fast in Photoshop and rarely have a use for Lightroom. It also bogs down my machine heavily...
And I need to layer ALL my images for one reason or another.
In Photoshop, I never use 3D.
But i have made animated gifs, I use type, I use about 20% of the filters, i've been known to vector-layer from time to time, i use paths and channels heavily, I'm always doing custom CMYK conversions...
I'd be afraid that some sort of Photoshop replacement would require learning a new language so to speak. The tools in Photoshop have become second nature to most of us.
(hello Jeff, i hope you are well in Chi-Town)