My uninformed prediction is that you will end up going back to the location you scouted, and shooting a bunch more images for a high-resolution stitch. Unless people aren't going to ever get particularly close to the mural.
Again, it's just my guess, but having worked with resizing programs a bit, I don't think that there will be much visible difference between 150 ppi and 75 ppi - they're just not that great at resizing complex foliage (of course, your mileage may vary). But it should be interesting to see how the RIP handles a 150ppi file.
By comparison I just printed a forest pano a mere eight feet wide - it was a 24 image stitch from a D800E, although I overdid it - it would have been fine as maybe an 8 image stitch. People seem to walk right up to it to look for detail.
Good luck.