Are you having issues with the reproduction of a particular color, relative to the others? That is, most colors are fine, but the blue isn't quite right? (Or whatever color...) If so, the HSL tab in Lightroom allows some specific control over how color is interpreted. It's a global control, so it affects all the blue, for example. I use it fairly often, for subtle adjustments to, say, the color of the sky, or a skin tone that is too ruddy.
If you're really having a very local problem, isolated to one particular part of the image, then making local adjustments is perfectly fine, in my opinion anyway. The whole idea is that you need to match the original artwork, so have at it.