I always thought so, and for many years was on a trajectory of larger cameras, enlargers and print sizes. What I've begun to realize is that it's getting increasingly difficult to justify the expense of the equipment, the weight of the gear, and the size of the facility geared towards making really large images. Getting profit out of the process of photography in the 21st century seems to be very hard compared to only 20 years ago. People seem to spend more time looking at images on monitors, much commercial work is now for web, not print, and except for the very wealthy few, wall space for large prints is at a premium.
I recently added an Olympus OMD EM-5 kit to my gear (which at this point is Canon DSLR). The Oly kit has the body, 17mm, 45mm and 75mm f1/8 prime lenses, and in a Domke messenger back weighs just over 5 lbs.
I'm extremely happy with the results of this combination, both in print and on screen. It's a lot more fun to carry around this kit for a day, and it's allowing me to shoot more freely than the DSLR does. It's a really well thought out camera system that delivers pleasure during use, and amazing results.
Are there tradeoffs, yes. But no camera is perfect, and I'm happy I reevaluated my gear.