Spray with Breathing Color's Timeless varnish or PremierArt's ECO Print shield. I'm using the Timeless varnish applied with a Wagner Control Spray Max, as recommended by Breathing Color. I tried using a foam roller but I wasn't able to get an even coat on my 30x60" print.
For mounting board, I haven't figured out what to use yet. Dibond, masonite, Sintra, Gatorboard are options, just trying to find the best balance between permanence and price.