If you have any virus and/or spyware detecting software try disabling those for the sake of testing. You might disable scanning of, for example, .psd .tiff and so on. If possible disable that kind of thing for active monitoring, but enable it for doing weekly full system scans, or as you do.
Also check to see how much RAM PS is configured to use.
In Photoshop, make sure that the scratch drive is on a different location than the computer’s system drive (usually the C drive). Also while it’s typically a good idea to make sure that the windows paging file is on a separate drive from the computer’s system drive, with a SSD drive this may not be an issue.
I thought I read somewhere that cs6 does background saves, as a new feature of cs6. If this is the case, the save will probably be a lower priority process than it was previously. I don’t know if this feature is something that can be turned on or off.
If you have the Windows indexing service turned on, disable it.
In Windows, open task manager, click on the performance tab and open the resource manager. Do a single large file read and watch for bottle necks. Also do a single large file save and do the same. The bottle necks will show you where the performance issues are.