"many drum scan operators don't know what to do with color negatives. They use chrome settings. Color negs require a different aperture setting than chromes to get proper resolution"
Yeah, it's true that many drum scanner operators can't scan a color neg to save their ass, but others can. I've been matching aperture to film grain - and trust me - it's not just with color negs that this applies, it's also black and white and color transparencies as well. The basic premise is that you manually override the auto resolution/aperture setting where the scanning software automatically sets the aperture that matches that resolution - for example 4000 ppi = 6.35 micron aperture - and manually set an aperture that closely matches the film grain. The optimum aperture will depend on the film, the processing, the image, etc. and the scanners have the ability to to a small size "Detail" scan that can be viewed immediately in the scanning software and compared to another "Detail" scan to determine the best settings.
To give an idea of real world settings, a typical optimal aperture for Portra 160 is between 13 and 19 microns, while still scanning at 4000 ppi. If you use the Auto setting, you'll get the 6.35 micron aperture and also get super accentuated grain but with no increase in detail over a scan with the optimum aperture. Not all drum scanners have the same number and range of available apertures, so some models are more suited than others for fine tuning.
I recently scanned some 35mm Ektar 25 for a friend, and after looking at the Detail scans, it was apparent that that color neg film could easily take the 6.35 micron aperture native to the 4000 ppi res scan, so in that case, using the "chrome" settings were just fine. Just as important is the software's ability to invert the color neg orange mask and set the right end points for proper white and black values. Manual control of those values is crucial to a great color neg scan.
What a lot of people don't know is that on a drum scanner, the hardware optical resolutions are bunched at the lower end of the resolution ladder and spread out as the res goes up. For instance, on my Howtek 8000, the maximum res is 8000, but the next lower resolution is half of that at 4000, and then down to 2666. These numbers are directly related to the available aperture diameter behind the lens on the scanner. 3.17 microns = 8000 ppi, 6.35 microns = 4000 ppi, etc. There's nothing in between those two settings, so there are no hardware resolutions available no matter what someone claims. A 5000 ppi scan HAS to be made at 8000 and then sampled down. It's much faster these days to scan at the higher resolution and then sample it as needed in Ps. There's also no difference in scanning time for either 8 bit or 16 bit files for the same scan, so there's no reason not to always scan 16 bit. Anyone who charges you strictly by the megabyte for a scan is, well, it's probably not polite to say it here.