Generally, I think, if you run profiles, you don't have to get into UCR/GCR, dot gain, or other prepress techniques since you are building a LUT that translates what you see into what you print. The only changes I tend to make with my workflow very occasionally is to tweak the color, thickness and drydown in the the printer controls of the printer driver, not mess around with the images and make them only printable to me.
The goal of all this color management isn't to fool around deep in the menus, but to get as close as the technology will allow to WYSIWYG color so what you print on one printer with one set of inks on one paper is similar if the same on other printers/inks/papers.
If you don't think you'll ever change printers, papers, inks, then changing all these output settings may make sense, but be ware that you may though all your settings out of kilter.
Even when I did a lot of prepress, I seldom dealt with those settings and aspects of production since most of what I did pretty much reproduced just fine without much tweaking. But that was when my images went to film for the press. Today, I work predominately in RGB and if needed, I'll convert to CMYK if the work is going to press (post cards, brochures, catalogs) IF I'm doing the design. Otherwise, stick to RGB, get a good profiling system (I'm using the ColorMunki for both my displays and custom profiles), and spend your time crafting the best print you can!
