I've only been using CS6 for three days now and so far they three things that make it worthwhile for me are the new feathering limit on selections, up to 1000 pixels from 250, the gigantic 15,000 pixel brush in Liquefy, and the doubling of brush sizes to 5000 pixels. The new interface is a big step backward being less legible than the previous version, but wtf do I know. I don't care about background saves. In fact, there are often times when I would NOT want something saved automatically. The new filters may or may not prove useful. Too soon to tell, but the crop tool is a complete mess. Too often with Adobe (and many other companies) there is change for the sake of change without a lot of thought to why changes are being made, and while I'm sure they will claim they put a lot of thought into these changes, I'm not that impressed. So for me, it's a mixed bag, some positive, some negative but nothing completely overwhelming at this point.