I used to have an Olympus 2100 - that 38-280 sure brought things in close. For depth of field, you can't do better than a smaller sensor camera stopped down to f8, camera mounted on a tripod. Even then, at 380 mm. the depth of field isn't that huge. There are new replacements for the 2100 - eg. Olympus 750, the new Canon IS and Minolta Z2. I have to say that with long lenses (35 mm. equiv. of 3800) the image stabilization (which was canon's and olympus just bought their lens for the 2100) makes sense therfore suggesting the Canon IS would be your best bet. If you want really top quality prints and don't need to be at 380 mm., consider stitching.