This just started happening today with LR 4.1RC, which I have been using for about a week without seeing this, and this was not happening with LR 4.0. When sending to Photoshop for editing, the photo becomes brighter and loses some contrast, without me doing anything in Photoshop, and this change remains when saving back to Lightroom. Could this be a bug, or is it something on my end that has changed? I have not changed my Lightroom preferences.