Yesterday I had a local lab print a 50% crop version of an ISO 800 5Dmk3 image at 20 x14 inches. The lens was Canon's latest 24-105mm f/4L. I needed ISO 800 for the situation to get the depth of field I needed and a short shutter speed (outdoor group portrait of school kids in dappled but mostly shady light - location dictated by circumstances beyond my control).
I followed Jeff's recommendations about nr and resolution settings and used my eyes to fine tune the settings in Lr4.
The results were very fine. Lots and lots of fine detail and and very large dynamic range. Excellent color saturation and pleasing "accuracy" of skin tones. Virtually every shade of Asian, Caucasian, Hispanic, Negro, and mixed heritage skin tone was represented in the group along with all shades and textures of natural hair color and eye color.
Printing was done on a current large format Epeon on Epson's Ultra Premium Photo Luster paper and the Raw file had been processed as a DNG in Lightroom 4 and retouched in Photoshop.