Hi Bart,
The scanner is a Minolta Dimage Scan Elite 5400. I am using an imac with OS 10.5.6.
I did a test with the Minolta software and that came out fine, like before. The lines on the Vuescan are horizontal across the scan (along the long side of the 35mm neg as it is drawn into the scanner). If I dump Vuescan in the trash and reinstall I just put in my serial number again right? Maybe this would solve the problem?
Best, Martin.