I posted this but it never showed up. Thanks to the History function in the browser it was still there, or here, now:
One thing I can tell you is that even on an extremely good drum scanner, scanning at 8000 ppi, using a 3.17 micron aperture spot, the scanner will not record everything that is on the film. I had always been told that it would, but taking an extremely sharp piece of Velvia 35mm film that had been shot at f/4 with a Canon 200mm 1.8 on a heavy tripod with mirror lockup, etc. I was able to see more detail on the film than I could record with the scanner. I didn't have a microscope, but I did have a Beseler 45M racked all the way up, focusing through an Omega grain focuser, and through that, there was clearly more on the film. Not a lot, but enough to see. A microscope would have probably seen even a greater difference.
The problem, of course, is how to get it off the film, as every optical system has its losses. In my experience, the least amount of optical losses are in the drum scanner's optical system, which only has to record an area far less than a square millimeter at a time, using the sharpest part of a very expensive optimized lens versus, in this case, a macro lens recording the entire image at once. The drum scanning/digital print combination seems to be the best way to get the sharpest prints with the best tonal qualities compared to any other, including direct optical printing, which seems to incur more overall losses with the combination of enlarging lens and paper resolution than the scanner route.
I don't have the reference on this computer and don't feel like researching it right now, but there are people out there obsessed with this sort of stuff, and have measured on medium format cameras, with the Mamiya 7 80mm lens being one of the best overall, actual on T-Max100 film resolution numbers of 120 lines per millimeter in the center of the lens. I think the surprising thing also was that some of those medium format lenses far outperformed the best 35mm lenses, challenging the common wisdom that the smaller the format, the sharper the lens. If we only had Technical Pan still readily available.