I would turn off turn off ANC, as I feel it's one of the greatest ways to waste ink Epson ever designed and leave it off.
I always clean in Serviceman mode where you get much better control of the amount of ink being used in the cleaning, CL1-CL4 pairs cleaning.
ANC will do a cleaning even if only one strip is missing on one nozzle. I don't believe that when ANC cleans, it does a pairs cleaning, but instead cleans the entire head. This is also wasteful since you can print fine with a few bars missing and many times printing will clean out the few missing bars.
Power up in Serviceman mode, run a Nozzle check from your computer, if you have a clog, clean it from the printer LCD CL-1 through CL4, I have yet to go past CL2 with my 9900. You can print from Serviceman mode also, I tend to leave my machine in that mode. Only difference I have found is you can't set the Platen gap or paper type from the printer's LCD, instead do it from the driver.
Not a perfect solution, but one that works and will drastically cut down on the ink waste you get.
Paul Caldwell