At some point resolution of the sensor becomes so high that the limitations in the lens resolving power start to show, and also diffraction. Modern APS-C sensors is a good example of this 18 megapixel on the Canon 7D and 24 megapixels on the Sony SLT-A77, scaled to full-frame 135 it would be 45 - 56 megapixels.
The common view on this is that it is a waste and that you instead want high contrast sharp images down to the pixel level, that is lower resolution (unnecessary to outresolve lenses / or sample diffraction) and no AA filter.
However, from recent prints and experiments with upscaling software I've made it seems to me that you'd not want sharp images at the pixel level, because they won't scale up well. Jaggies in sharp diagonal contrasty lines will show as artifacts / false detail after upscaling. The most visually pleasing upscaling result I get is from simple bilinear (or perhaps rather bicubic) interpolation when the original image is fuzzy enough at the pixel level so that no jaggies exist in the original image, and then no false detail is introduced after upscaling.
Thus, to me it seems better for image quality to print an image at say 300 ppi where pixels are a bit fuzzy than print at 200 ppi with sharp pixels even if actual detail is the same. And if you need to scale up the image, having sharp pixels is not necessarily an advantage. For a print, the image usually need to be rescaled some to match the printer resolution, there is rarely an exact match with the photo pixel resolution. (The c-printer I use seems to use bilinear scaling to match the input with printer resolution.)
Another aspect is if you do lens distortion correction in post (correct barrell distortion etc) or rotate the image etc, this will show less artifacts if the image is not too sharp at pixel level.
Sure you can blur down the pixelsharp image before upscaling etc, but it seems to me that you will then lose more resolution than if you from the start had a suitable over-resolution which do not require blurring. Where the limits are I'm not sure though. On full-frame 135 I'm quite sure you'd rather have 40 megapixels with AA filter than 20 megapixels without if you want to make large prints.
What do you think?