I think the most important thing is to find a workflow that suits you, because we are all going end up with a lot of files and we need to be able to access them easily.
Which is more valuable: your time or your hard drive space? For me it's my time, so I never flatten a tiff and I don't care if I have several versions of a file as long as they have unique names so they can never be mixed up. As printer technology improves I find I have to go back and re-do layers in files to correct faults that were originally invisible.
FWIW, here's my set up. Your mileage may vary.
I start with a folder for the year. E.g. PHOTOGRAPHS 2009. Capital letters mean a major file.
Then a folder for the shoot with the date and some information e.g. 20090926timbuktuzoo. This name is also in the filename of each image..
Then usually three subfolders: Raw, Edits and Print. Self-explanatory. The edited tiffs have the softproofing in the top layer which is turned off. There may be two or three softproofing layers if I am trying out different papers. The only exception is when the file size is well over 1 gb. It takes too long to open and edit so I copy the file and flatten the layers and call it filenameMaster_1. Then carry on with the editing.
For printing I turn on the relevant softproof layer and flatten the file, set it to the correct document size for the print I want and paste it onto a white background to give me a border, and save it in the Print folder. I append the details to the file name e.g. FilenameSpIlGFSRelCanned6300 means softproofed for Ilford Gold Fibre Silk, relative rendering intent, using Ilford's profile for the Canon 6300 printer. Any other notes are added to the metadata in LR (e.g. paper size).
In Qimage I have the paper size, printer specifications, profile, rendering intent, sharpening and so on saved as presets, so I just hit Recall. In LR I right-click and select “Edit in Qimage” and am good to go.
I really recommend you support this site and yourself and get the videos.