It's very simple, you just select optimize profile from main menu, then select the profile from the list you want to optimize.
Follow the on screen instructions, generate some patches using "smart patch generator", then at the "spot colors" load the 256grays txt file.
Print and measure the target.
However if your print changes to a noticeable amount you can't optimize the print, you need to make new profile from scratch.
Optimization can only be performed if the print is stable.