Now have printed to 3880 and 11880 with no problems. Testing i1Profiler with i1iO table (worried about the dongle, it's broke on new system software installs before) over the weekend. (3 day weekend here in Utah) Only issue so far is ColorThink Pro is not compatible, but the beta version from them seems to be working fine. Worked extensively with CS5, LRv3, and C1v6, also done quite a bit of file copying and backing up. Driver for my eSata card broke again, but patch has been available for some time, so after than my external drives running fine.
Haven't run into any other compatibility problems yet, one program I use called camouflage (hides the desktop) was flagged on the install as incompatible still works .. a couple of visual issues but it isn't a Rosetta issue.
My son-in-law says his macbook pro seems to have some issues with Lion, running slow and crashed a couple of times. He's a programmer so he uses different software than I do.
Pretty comfortable with Lion, so now running on laptop (after a full cloned backup just in case).