I've got a studio full of Epson printers, 4000, 7600, 9800, 9900, 3880, and go out for one to four weeks at a time, simply turning off the printers when I'm gone.
Sometimes, I've got to run a cleaning cycle, other times, it's as though I printed yesterday.
If you are using non-fine-art or canvas to print upon, you'll probably have less dust and lint clogging the heads.
Usually, when I get home and start printing after an absence, I simply run a nozzle check and if it's good, start printing. Usually, I have a slight gab in one-two colors and then need to run a cleaning cycle.
The main issues for print and leave is probably every few months to pull the carts, shake them and reinstall, along with doing a nozzle check at the start of your printing sessions.
Usually, in my experience, you'll simply need to run a check and then you'll be sure that the images will print fine.