The only really effective anti glare acrylic is Optium, which is a very expensive option.
Some galleries now forbid glass on largish pieces for insurance purposes. Acrylic doesn't cause shrapnel damage to the artwork or nearby human bodies if the frame falls.
As mentioned, acrylic scratches easily and sometimes a sheet you thought was immaculate will look awful under a gallery spotlight. One well meaning cleaning attempt by a clueless person can create countless scratches. Also, if the frame puts the slightest amount of pinch or warp on the sheet, you get funhouse mirror effects in the reflections. Acrylic framing packages must be put together rather loose, you should be able to feel the artwork package shifting around slightly when you tilt the frame. Also tape sealing the inner artwork package against dust it not a very good idea for acrylic, again because of surface distortions.
The most common framing grade of acrylic is Acrylite-FF, costs about $67 for a 4x8 foot sheet at Piedmont. They'll cut a sheet up any way want for about $15.